Saint Joseph Academy is the only all-female Catholic high school located in Cleveland, Ohio. It is located in the Roman Catholic Diocese of Cleveland. The average class size is 19.5 students per class, and students may choose from more than 120 courses, including 18 AP classes and 30 Honors courses. Eighty-five percent of Saint Joseph Academy students are Catholic, and, all together, students completed more than 29,000 hours of service in the 2017-18 academic year. In addition, a Sister of St. Joseph serves as Vice President of Mission, and six faculty and staff members are Associates of the Congregation of St. Joseph.

Ninety-eight percent of the Class of 2018 was accepted to colleges and universities across the country, and they received more than 17.1 dollars in merit-based college scholarship awards. There was 1 National Merit Finalist and 8 National Merit Commended Scholars in the Class of 2018.